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Fisetin Supplement 98% – Antioxidant, Senolytic, Anti-Aging


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Fisetin is a natural flavonoid that is studied for the antioxidant, anti-inflammatory effects and the support it may provide for on healthspan.


Fisetin Supplement 98% is a naturally occurring flavonoid polyphenol found in certain fruits and vegetables, such as strawberries (160 mg/kg), apples (30 mg/kg), onions, cucumbers, and persimmons. The compound is still largely unknown compared to most other antioxidants, such as resveratrol.

More recently it has garnered interest from scientists for its medicinal potential. Particularly there is an interest in studying the ability of the polyphenol to slow the aging process and extend human and animal lifespans, which is called the senolytic effect. The beneficial potential of the premium fisetin supplement 98% is exciting is classified as a dietary supplement and thus readily available to most people.

Other research have shown the substance has potent anti-inflammatory and antioxidant effects, can protect the brain, supports proper the blood sugar levels, builds bone strength, can help protect the liver and heart, and may have anticancerigen properties. It appears that it supports improved neural communication, which in turn boosts cognitive processes and memory function.


Some research suggests that fisetin may have anti-aging effects that contribute to healthspan and longevity. The flavonol influences cellular pathways that protects cells from damage and supports cellular function. A recent scientific study tested ten flavonoids for the effect on extending the lifespan in rodents. Fisetin supplement came out at the top as the most potent senolytic. The supplement reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. When given to mice late in life it restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.

Cognition and Learning

Fisetin supplement has shown promise in supporting cognitive health. Preclinical studies of healthy rodents suggest that fisetin may strengthen the connections between brain cells and facilitate long-term memory. It activates extracellular signal-regulated kinase (ERK) which is implicated in several different signaling pathways for memory and learning, including brain-derived neurotrophic factor (BDNF) receptors and N-methyl-D-aspartate (NMDA) pathway.


It may have neuroprotective effects by promoting the survival of nerve cells, reducing oxidative stress, and potentially slowing down the progression of age-related cognitive decline and neurodegenerative diseases. Studies of Alzheimer’s disease in animals suggest the compound may lower levels of aggregated beta-amyloid and phosphorylated tau, lower levels of neuroinflammation, and as a prophylactic during the development of memory deficits.


The flavonoid may support cardiovascular health by reducing oxidative stress, inflammation, and improving blood vessel function. These effects contribute to overall heart health and may help lower the risk of cardiovascular diseases.

Blood Sugar

Fisetin has been studied for its potential to regulate blood sugar levels. It may enhance insulin sensitivity, improve glucose metabolism, and contribute to better blood sugar control. These effects are particularly relevant for individuals managing diabetes or at risk of insulin resistance.


Fisetin has been studied for its anti-inflammatory properties. It may help modulate inflammatory responses in the body, reducing chronic inflammation associated with various health conditions, including cardiovascular diseases and neurodegenerative disorders.

Tumor Prevention

Fisetin has been investigated for its potential anti-cancer properties. It may inhibit the growth of malignant cells and induce apoptosis (programmed cell death). While research is in the early stages, the ability to modulate various signaling pathways makes fisetin a subject of interest in prevention and treatment.


Some studies have explored the compound’s potential antiviral effects. It may have inhibitory effects against certain viruses, contributing to immune system support and viral infection prevention.


Premium fisetin is a potent antioxidant that helps neutralize free radicals in the body. Free radicals are reactive molecules that can cause oxidative stress, leading to cellular damage and contributing to aging and various diseases. The antioxidant activity supports overall cellular health.

Joint Health

The anti-inflammatory properties may extend to joint health. It may help alleviate inflammation and provide support for individuals dealing with joint conditions, such as arthritis.

Skin Protection

The supplement may contribute to skin protection and health. Its antioxidant properties help combat oxidative stress and may contribute to a reduction in skin aging, promoting a more youthful appearance.

Suggested use

The suggested daily amount is from 200 mg to 1,500 mg.


Premium Fisetin supplement 98% (HPLC Normalization Method). The plant source material is Cotinus coggygria (Smoke tree). Appearance is pale yellow.


The various effects are not guaranteed and results may vary due to several factors between different people.

We strive to ensure the accuracy of the information provided by the manufacturers and recommend that you read all labels and warnings. However, the information is not a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment.

Premium Fisetin Supplement 98% is made from Cotinus Coggygria
Fisetin 98% made from Cotinus Coggygria
Weight (Bag)

100g (3.5oz), 200g (7.1oz), 50g (1.8oz)


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