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Calcium Alpha-Ketoglutarate (Ca-AKG) – Aging, Brown Fats


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Calcium Alpha Ketoglutarate (Ca-AKG) is involved in the epigenetic modulation, collagen synthesis, metabolism, and cellular aging.


Calcium Alpha Ketoglutarate (Ca-AKG) is a particular form of mineral calcium that is involved in the epigenetic modulation, collagen synthesis, metabolism, mitochondrial energy production, and cellular aging. The substance that our bodies produce naturally begin to decline with age, just like many other important health indicators. One study found at the age of 80 our levels can be 10x lower than they are at age 40.

Calcium Alpha-Ketoglutarate plays a key role in the body by activating AMPK signaling and inhibiting the mTOR pathway. AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) are two of the principal pathways that affect aging and lifespan.

One explanation for the longevity effect is that calcium alpha-ketoglutarate (Ca-AKG) affects epigenetic processes. The complex molecular system that surrounds the DNA and controls when genes are turned “on” or “off” is known as the epigenome. These chemical modifications regulate gene expression while it does not change the DNA itself. The epigenome becomes progressively dysregulated as we age, which means that some genes that ought to be silent are turned “on”, while others that need to be active, like cancer protective genes, are turned “off”.

With time this dysregulation results in an ever increasing accumulation of epigenetic errors, which we can see as methylation of our epigenome. In recent years scientists have developed biological clocks, such as the Horvath clock, which can measure the aging of our bodies much more exactly than the chronological age. Ca-AKG helps by modulating the methylation of the epigenome.

The metabolism of amino acids and carbohydrates is also connected through calcium alpha-ketoglutarate. Our cells’ ability to switch between using amino acids and carbohydrates to make energy decreases as we age. However, Ca-AKG can support cells’ continued maintenance of this metabolic adaptability. Moreover, it functions as an energy source for the cellular mitochondria and enhances mitochondrial health. This is why the compound is popular among athletes and bodybuilders that strive to increase energy and endurance.

Lifespan and Healthspan

Several studies show animals live longer when given Ca-AKG. For instance, in a study of mice Ca-AKG enhanced health span by 41% and lifespan by 12%.

Cellular Energy

The power generators of our cells, the mitochondria, use alpha-ketoglutarate as fuel and the health of the mitochondria is improved by the substance.

Epigenome Function

Our epigenome benefits as Ca-AKG helps to control which genes in the epigenome are activated or deactivated.

Brown Fat Cells

It assist in maintaining weight and in altering our unhealthy white fats into brown fats.


Calcium alpha ketoglutarate decreases levels of inflammatory cytokines and reducing the inflammation caused by senescent cells.

Suggested use

The suggested dose is 800 – 1200 mg daily (approximately 1/4 teaspoon). It should preferably be taken during the morning without food.


Calcium Alpha Ketoglutarate (Ca-AKG) 99%+. No other ingredients.


The various effects are not guaranteed and results may vary due to several factors between different people.

We strive to ensure the accuracy of the information provided by the manufacturers and recommend that you read all labels and warnings. However, the information is not a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment.

Weight (Bag)

1000g (35.3oz), 100g (3.5oz), 200g (7.1oz), 500g (17.6oz)


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